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Heart Attack (MI) Nursing: Signs, Priorities, and Meds

Cardiac · Written by Professor Foxx, RN, MSN · Updated October 2026

A heart attack (myocardial infarction, or MI) happens when blood flow to part of the heart muscle is blocked. Every minute counts, because heart muscle dies without oxygen.

Signs

First actions

  1. Call for help and stay with the patient.
  2. 12-lead ECG within 10 minutes of arrival or of the chest pain starting.
  3. Oxygen if SpO2 is below 90%.
  4. Aspirin 162 to 325 mg, chewed, unless the patient is allergic or the provider says no.
  5. Nitroglycerin 0.4 mg under the tongue every 5 minutes, up to 3 doses, if ordered and BP allows.
  6. IV access and labs, including troponin.

When to hold nitroglycerin

STEMI vs. NSTEMI

STEMINSTEMI
ECGST elevationNo ST elevation (may have ST depression or T wave changes)
TroponinElevatedElevated
TreatmentEmergency cath lab to open the artery, ideally within 90 minutes of arrivalMedications, then cath based on risk

Troponin

Troponin is the main lab for heart muscle damage. It rises within hours and stays up for days, so it is usually checked more than once.

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Quick answers

What is the first thing to do for a patient with chest pain?

Stay with the patient, call for help, and get a 12-lead ECG within 10 minutes, then give oxygen if SpO2 is under 90%, aspirin, and nitroglycerin as ordered.

When should nitroglycerin be held?

Hold it if systolic BP is below 90 mm Hg, if the patient took sildenafil or a similar drug recently, or if the provider suspects a right ventricular MI.

Evidence & Clinical Sources

Reviewed against current guidelines and drug labels. Always follow your program, a current drug reference, and facility policy. Our sources policy

For learning only. Lab ranges and policies vary. Always follow your nursing program, a current drug reference, and your facility's policies.

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